To clear thing up this is a pure auto attack Regeneration Master build, so if you like a more Overkill chaser oriented build you haven't tried this baby out. What you will need to do is simple:
1)Lane and become a regen glob kleptomaniac.
2)Flip camps as often as possible to get those regen globs stacking.

This will help Tychusby adding more healing regen to his AA and make him withstand more damage than your opponents can dish on you. Remember REGEN GLOBS are your bread and butter for this build, so a helpful reminder. ALWAYS KILL THE MAGE MINIONS FIRST.

It can get dull when the only thing you are doing is laning for globs, you can always go ahead and help other lanes in order to spice things up a bit, however, you might want to avoid team fights until Tychus gets Vampiric Assault. At this point if you are feeling brave you will also be able to start flipping SIEGE camps so make the most of it as mercenaries can change the tides of battle quite fast.

You will be surprised how useful it is to use Run and Gun not only to close those gaps or strategically dodge and retreat, but to get that attack speed going with Rapid Fire. This is what is going to give us that amazing regen. I often use Run and Gun as the start up move to engage a mercenary camp then follow up with the Frag Grenade. You will see the increased attack speed while those green numbers just show up faster than you can count them. At this point you will also be able to flip BRUISER camps on your own, however, be wary when you do since these take up more time and things can go wrong very fast.

Once you've reached Drakken Laser Drill you should have decent amount health regen to get you going. You should also be able to take on turrets by auto attack without dying. Now use your ult to block in enemies from running away while you Run and Gun them down. This tactic is very effective and will almost always work, just be wary on 2 vs 1 since the Drakken Laser Drill will automatically target the closest Hero on sight while you might be targeting the second Hero, hence minimizing the damage output. ALWAYS aim at the same Hero your Laser aims at to maximize damage and regen.

By using Problem Solver your damage to tanks will be unpaired and you should be able to easily beat them to a pulp while healing up. This is specially useful when defending Keeps or pushing lanes. Just remember that you are not a TANK you will be able to heal up very fast, however, your enemies will also be dealing more damage as their levels go up so be careful as to whom you try and take on. Nuff Said.

When you hit this Executioner baby you want to jump right into team battles and aim for any stunned, slowed or rooted target, pretty self explanatory. Always remember to Run and Gun prior to any fight since your AA will be the key to your survivability. You can always retreat since your regen should be enough to heal Tychus up. At this point you can flip camps to heal up so no Heart stoning unless you are out of MANA and you can't Run and Gun. This is the beauty of this build, you are one of the most sustainable Heroes out there since you heal as you lane or flip camps.

If you weren't healing fast enough at this point I bid you welcome to Nexus Frenzy. Not only is your AA fast as F..k now, but also your AA range is increased. You should have 8 to 10 stacks of regen at this point and be able to heal faster than any damage done to you. Pushing towers, keeps, and else should be piece of cake. You could even flip a boss with just another support or go around the map flipping camps left and right confusing the enemy as to where to defend next.

Your Drakken Laser Drill is very important as it will help you to take any extra HERO damage off you. In plenty of occasions I've seen Heroes attack me as the Laser just drains their hp and I heal back up. Also its very useful If you really want to keep those pesky nova's or zeratul's on check while bringing an extra HMPH of damage to any lane you are pushing. What works most of the times for team fights is starting by positioning the laser BEHIND foes and then engaging as you see them run off getting their ***es burnt.

This is just my build and how I love to play Tychus. You can use different skills that might suit your very needs at the moment and your overall playstyle. Personally I just take advantage of the really fast AA minigun damage to make me a very sustainable, damage dealing foe. If this build gets any attention I will be more than happy to update and add videos in order to get a better idea on the how to play aspect.

But seriously, give it a try you might just like it.