I personally always go with an Hybrid build:

1a - Dampen Magic (if enemy team is "ability heavy")
1b - Chew Your Food (if the above statement is false)
2 - Always go Putrid Ground, it gives you wave clear potential and the Gas ticks are nasty against stealth heroes
3 - Last Bite 90% of the times for massive self heal, few times Tenderize or Toxic Gas
4 - I like Hook+Gorge combo too much... i'd take Arthas if i wanted the slow effect
5 - Mega Smash 90% of the times, the more stuff we hit the better
6 - Pulverize "closes" the build, we now have a HUGE 75%CC + dmg + dot every 6 seconds, none can escape!
7 - Bolt of the Storm 100% cuz i love to turn 5v5 into 4v5 and for emergencies

Hi, just a quick comment: Last Bite also works on minions and reduces the cooldown "by 15 sec" instead of "to 15 sec" which means you can basically heal to full with one minion wave.